Life Extension

Uric Acid Control

Evidence: Limited

Terminalia bellerica, rated Limited as an ingredient, 500 mg per serving, at or above the lowest studied dose of 500 mg a day. No USP, NSF or Informed Choice verification shown.

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What studies found on terminalia bellerica

Limited 2 randomized trials from 1 research group in Hyderabad (Usharani 2016, n=110 with placebo, and Pingali 2020, n=59 in kidney disease against febuxostat) found serum uric acid fell on the extract, but neither enrolled people with diagnosed gout and the 2020 trial was registered after it began.

Studied dose: 500 to 2,000 mg aqueous extract a day (250 to 1,000 mg twice daily).

  • Usharani P 2016, Clin Pharmacol. Randomized double-blind placebo- and febuxostat-controlled pilot trial, 110 people, 24 weeks. In people with high uric acid, serum uric acid fell from 8.07 to 5.78 mg/dL on 500 mg twice daily, compared with 8.53 to 4.28 mg/dL on febuxostat, and rose on placebo.
  • Pingali U 2020, BMC Complement Med Ther. Randomized double-blind febuxostat-controlled dose-response trial, 59 people, 24 weeks. In people with chronic kidney disease and high uric acid, serum uric acid fell 19.8% on 500 mg and 33.9% on 1,000 mg twice daily, compared with 63.7% on febuxostat, with no placebo arm.

Safety: Pingali 2020 (n=59) reported no effect on platelet aggregation. Neither trial tested the extract taken with allopurinol, febuxostat or colchicine. Talk to your doctor before starting a supplement, especially if you take allopurinol, febuxostat or colchicine.

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