Supplements, rated on the evidence
46 supplements people with gout ask about, rated on 41 human studies of their ingredients, the dose on the label against the dose studied, named third-party testing, and whether a blend discloses its amounts. A rating describes the evidence, not what a product will do for you. The best-studied option for lowering uric acid is prescription medicine, so talk to your doctor first, especially if you take allopurinol, febuxostat or colchicine.
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What the studies found, by ingredient
| Ingredient | Evidence | Why | Studies |
|---|---|---|---|
| Vitamin C | Moderate | 2 meta-analyses of randomized trials (13 trials, 556 people in 2011 and 16 trials, 1,013 people in 2021) found a small, consistent drop in serum urate, about 0.35 mg/dL, and a 20-year cohort of 46,994 men linked higher intake to fewer new gout cases, while the 1 trial in people with gout (Stamp 2013, n=40) found a change too small to matter clinically. | Juraschek SP 2011 Liu XX 2021 Huang HY 2005 Stamp LK 2013 Choi HK 2009 Andrés M 2021 Ferraro PM 2016 |
| Celery seed | Limited | The only human trial found (Escobedo-Gutierrez 2026) enrolled 28 people with metabolic syndrome, not gout, and reported uric acid as a secondary result within the celery seed group. | Escobedo-Gutiérrez MJ 2026 |
| Folic acid | Limited | The largest trial (Qin 2017, 15,364 adults with high blood pressure) found serum uric acid rose 4.0 µmol/L (about 0.07 mg/dL) less over 4.4 years with folic acid, a very small difference, an 8-week trial (n=450) found no overall change, and no trial enrolled people with gout. | Qin X 2017 Li H 2015 Ye G 2025 |
| Quercetin | Limited | 1 small placebo-controlled crossover trial (Shi 2016, n=22 healthy men) found a drop in plasma uric acid, and the other human data are non-randomized real-life cohorts reported by authors with industry ties, with no trial in people with gout. | Shi Y 2016 Di Pierro F 2025 |
| Tart cherry (juice, concentrate, extract) | Limited | The largest placebo-controlled trial in people with gout (Stamp 2020, n=50) found no change in serum urate over 28 days at any dose, a 2026 meta-analysis of 4 trials (392 people) found a small pooled drop with high heterogeneity, and the flare data come from 1 observational case-crossover study (Zhang 2012, n=633). | Stamp LK 2020 Zhang Z 2026 Zhang Y 2012 Singh JA 2020 Wang C 2023 Jäger R 2026 Hillman AR 2021 Gonzalez DE 2024 Lamb KL 2026 |
| Terminalia bellerica | Limited | 2 randomized trials from 1 research group in Hyderabad (Usharani 2016, n=110 with placebo, and Pingali 2020, n=59 in kidney disease against febuxostat) found serum uric acid fell on the extract, but neither enrolled people with diagnosed gout and the 2020 trial was registered after it began. | Usharani P 2016 Pingali U 2020 |
| Turmeric / curcumin | Limited | The only placebo-controlled trial in people with high uric acid (Bupparenoo 2021, n=39) found curcumin no better than placebo, and the positive trial (Panahi 2016, n=87) enrolled people with fatty liver disease, not gout. | Bupparenoo P 2021 Panahi Y 2016 Halegoua-DeMarzio D 2023 |
| 'Uric acid support' blends | Insufficient | No published trial of any retail 'uric acid support' blend was found on 2026-10-06, a 2021 Cochrane review found only 2 eligible supplement trials in chronic gout, and a 2025 review of 27 trials called the evidence inconclusive, so each blend is rated on its ingredients and label. | Andrés M 2021 Pardali EC 2025 |
| Apple cider vinegar | Insufficient | A PubMed search on 2026-10-06 found no human study of apple cider vinegar on serum urate or gout flares. | |
| Black cherry (concentrate, extract) | Insufficient | No trial of black cherry concentrate or extract on serum urate or flares was found, and the closest study is a 2003 test of 280 g of fresh Bing sweet cherries in 10 healthy women measured over 5 hours. | Jacob RA 2003 Matout M 2019 |
| Bromelain | Insufficient | A PubMed search on 2026-10-06 found no human study of bromelain on serum urate or gout flares. | |
| Chanca piedra (Phyllanthus niruri) | Insufficient | Human studies of chanca piedra measured kidney stones, and the one that reported serum uric acid (Pucci 2018, n=56, no control group) found no change. | Pucci ND 2018 |
| Coffee and caffeine pills | Insufficient | No trial of caffeine pills on serum urate or flares was found, and while large cohorts link drinking coffee, including decaf, to lower gout risk, total caffeine was not associated with gout in men (Choi 2007, n=45,869) or with serum uric acid in US adults (Choi 2007, n=14,758). | Choi HK 2007 Choi HK 2010 Choi HK 2007 Guo H 2023 Park KY 2016 |
| Dandelion | Insufficient | A PubMed search on 2026-10-06 found no human study of dandelion on serum urate or gout flares. | |
| Devil's claw | Insufficient | A PubMed search on 2026-10-06 found no human study of devil's claw on serum urate or gout flares. | |
| Stinging nettle | Insufficient | A PubMed search on 2026-10-06 found no human trial of a nettle supplement on serum urate or gout flares, and the only related trial (2020) tested homeopathic medicines with Urtica urens tincture. | |
| Fish oil / omega-3 | Evidence against | Each of the 3 human studies of omega-3 supplements in gout found no difference - no serum urate change in a 24-week trial (Stamp 2022, n=40), no difference in flares in a 28-week placebo trial (Abhishek 2022, n=60), and no flare association for self-directed supplements (Zhang 2019, n=724) - though all 3 were small or not designed to test efficacy. | Stamp LK 2022 Abhishek A 2022 Zhang M 2019 Gencer B 2021 |
Products, ranked by evidence
Ranked by evidence rating, then named third-party testing, then disclosed blends. Labels read 2026-10-06.