Nature Made

Folic Acid 400 mcg

Evidence: Limited

Folic acid, rated Limited as an ingredient, 400 mcg per serving, at or above the lowest studied dose of 400 mcg a day. Third-party verification shown: USP Verified.

We earn a commission when you buy through paid links on this page, at no extra cost to you. It never changes a rating or a ranking. As an Amazon Associate I earn from qualifying purchases. How we stay independent.

Check price at Amazon Brand label we read

On the label

What studies found on folic acid

Limited The largest trial (Qin 2017, 15,364 adults with high blood pressure) found serum uric acid rose 4.0 µmol/L (about 0.07 mg/dL) less over 4.4 years with folic acid, a very small difference, an 8-week trial (n=450) found no overall change, and no trial enrolled people with gout.

Studied dose: 0.4 to 0.8 mg (400 to 800 mcg) folic acid a day, given with enalapril.

  • Qin X 2017, Am J Clin Nutr. Randomized double-blind trial (CSPPT substudy), 15364 people, Median 4.4 years. Serum uric acid rose in both groups, by 4.0 µmol/L less with folic acid, and new high uric acid was slightly less common (15.0% vs 16.3%).
  • Li H 2015, Intern Med. Randomized double-blind controlled trial, 450 people, 8 weeks. Overall, uric acid did not differ between groups, and a difference appeared only in a subgroup with higher baseline uric acid on 0.8 mg.
  • Ye G 2025, Nutr Metab (Lond). Network meta-analysis of randomized trials, 44972 people, Varied by trial. Folic acid ranked with a pooled uric acid difference of -57.6 µmol/L vs conventional therapy, with a wide confidence interval (-107.1 to -8.1).

Safety: MedlinePlus advises telling your doctor and pharmacist about all supplements you take with folic acid (medlineplus.gov/druginfo/meds/a682591.html). Talk to your doctor before starting a supplement, especially if you take allopurinol, febuxostat or colchicine.

Other products with the same ingredient